The McLaren MP4/6 is a Formula One vehicle that was operated by the Marlboro McLaren Honda team in the 1991 Formula One World Championship.

The MP4/6 was the last F1 car to win a Championship with a manual gearbox and the only V12 powered F1 car to do so. It was also the last car Ayrton Senna won a Championship with.

1992, the MP4/6B (an improved version the MP4/6 with new front wing end-plates) was used for the first rounds of that year's season in South Africa and Mexico before being replaced by the MP4/7A.