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Yakui-san (ヤクいさん, Yakui-san) is a very popular if not most popular Nijiura Maid in the west. Her name comes from the words medicine (やくじ, yakuji) and calamity. She is addicted to pharmaceuticals and is often pictured drooling or with a crazed look in her eye.
In the early days, she was recommended by Yuki Kotonomiya to be the rightful successor, but she was opposed by the other teachers of Megaku and disappeared.
She is the source of many different colored derivatives of maids. She is often featured on 4chan, perhaps because of her familiarity with drug-related issues.
Yakui-san is short because of her drug abuse. She has a purple bob-cut and maid outfit (sometimes the outfit is blue) with purple and white striped stockings. She is often pictured drooling or vomiting with a crazed look in her eyes.
Once a month, she is tied up and de-medicated to make her more mature. The handcuffs on her arms are a remnant of that time.
She was kicked out of her parents' house because she was messing with the products of her family's drugstore. Her knowledge of medicines is top-notch, ranging from happy powder to drugs undergoing clinical trials. She has access to both legitimate and illegitimate drugs, and is also able to prepare her own original preparations.
When off her drugs, she's rather sensible, and when she's on her game, she's funky and capable, but if she overdoses even a little, she's peaky and useless. When she's on her game, Yakui-san can see things she can't see and hear things she can't hear.
In Nijikaku, one of her attacks involves transporting the opponent to a spinning, brightly and starkly yellow and purple striped world, leading one to believe that she experiences psychedelic hallucinations regularly.
She has been known to give out advice on medicines to passerby in the drug store (notably Homeo), though whether this was good or bad advice is subject to speculation.
She draws a line in the sand when it comes to changing people's minds with drugs.
Because of her drug abuse she is a part of the Inappropriate Maids along with Shitai-san and Dorei-san.
Inappropriate Maids Shitai-san Dorei-san Nijiura Maid Nijiura Maids (List of maids)